Endocrine Abstracts

Background: Graves’ disease and Hashimoto’s thyroiditis are the most common autoimmune thyroid conditions. Hyperthyroidism following hypothyroidism is a rare phenomenon. Hypothyroidism was once thought to be a permanent state requiring lifelong replacement therapy but we have noted that there are increasing numbers of cases which are against this postulation. We would like to report 3 cases initially diagnosed with hypothyroidism and referred to us following developm...

Background: Pituitary hyperplasia is a relatively common yet frequently overlooked condition which can occur in both physiological and pathological states. Pregnancy is one of the most common conditions associated with physiological pituitary enlargement.Case Presentation: 22-year-old normally fit and well lady presented to AMU (acute medicine unit) with a week history of headache and 10-month history of amenorrhoea following cessation of combined contra...

Background: Familial hypocalciuric hypercalcaemia (FHH) is a rare benign autosomal dominant condition which causes life-long mild to moderate hypercalcaemia. It is usually underdiagnosed due to lack of symptoms in majority of patients and low rate of screening even among endocrinologists. Recent NHS England National Genomic Directory testing criteria for FHH recommend testing patients presenting with hypercalcaemia and calcium creatinine clearance ratio (CCCR)...

Introduction: Hypophysitis is the inflammation of the pituitary gland, characterised by hypopituitarism and pituitary enlargement. It can occur as primary (commonly lymphocytic, granulomatous or xanthomatous) or secondary to systemic disease, immunotherapy or sella-based pathologies.Case Presentation: A 30-year-old female was admitted to hospital with headache, fatigue, low mood and blurred vision, 3 months after having ...

A 58-year old previously independent man with background of poorly-controlled hypothyroidism, T2DM, hypertension, ischaemic cardiomyopathy, and CKD presented to hospital feeling generally unwell, with a dry cough. His regular medications included anti-hypertensives, L-thyroxine 50 μg daily, linagliptin, insulin, aspirin, atorvastatin, and thiamine. On admission, the TSH was 83 mIU/l, free T4 6.5 pmol/l and free T3 was 1.9 pmol/l; four months earlier, the TS...

Background : Adrenocortical cancer (ACC) is a very rare but aggressive tumour with annual incidence of 2 cases per million populations. Hypercalcaemia is a commonly encountered paraneoplastic manifestation of certain cancers such as lung, breast, kidney, gynaecological and neuroendocrine tumours but very rare in ACC. So far, there are only two cases of ACC and PTHrP-related hypercalcaemia reported in the literature.Case report: 32-year-old man presented ...